Pharma Antibiotic API Spironolacton Anti Estrogen Powder USP Standard

Pharma Antibiotic API Spironolacton Anti Estrogen Powder USP Standard

Description:

Spironolactone (INN, BAN, USAN) commonly referred to simply as spiro, and marketed primarily under the brand name Aldactone in most countries, is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. It is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body. It acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.
Spironolactone is a relatively old drug, having been introduced clinically in 1959. Futterman and Lemberg have predicted that spironolactone will be less commonly used in cardiovascular conditions (e.g., heart failure and hypertension) as the newer agents like the structurally-related compound eplerenone (also an aldosterone antagonist) are more selective and lack many of the side effects and actions of spironolactone that are undesirable in that particular patient population. However, spironolactone remains more widely used as an antiandrogen than eplerenone for patients in whom this effect is a main goal.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

In recent years, substantial results have been achieved in the study of the biosynthesis mechanism of lincomycin, and the biosynthetic pathway has become increasingly clear. Antibiotic drugs lincomycin hydrochloride, also known as chlorcemycin hydrochloride, Jiminlik, Jiemycin, Liksheng, lincolnmycin, lomycin, lincolnmycin hydrochloride, white crystalline powder at room temperature, slightly odorous or special odor, bitter taste, soluble in water or methanol, its hydrochloride form is commonly used in feed. This drug is a product of the growth of Streptomyces lincolnensis flora, a basic antibiotic of Lincosamides, by acting on the 50S subunit of the sensitive bacterial ribosome, preventing the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells, with bacteriostatic effect, but also has a bactericidal effect on highly sensitive bacteria at high concentrations.

Test ItemsSpecificationTest ResultsAppearanceAlmost white crystalline powderAlmost white crystalline powderIdentificationMeet the requirementsMeet the requirementsMelting range