Cialis / Tadalafil Male Enhancement Powder CAS 224785-90-4

Melting point:298-300°C

alpha D20 +71.0°

Flash point:2℃

storage temp. Hygroscopic, -20?C Freezer, Under Inert Atmosphere

solubility DMSO: soluble20mg/mL, clear

color white to beige

Vardenafil is a drug for erectile dysfunction in men and is the first-line treatment for erectile dysfunction. Developed by the German company Bayer, it was first listed in the United States in 2002. Like sildenafil, it belongs to the second generation of type 5 phosphodiesterase inhibitors, and the onset of action is very rapid, about 15~20 minutes. The effect is ten times stronger than sildenafil. Clinical data show that 50%~60% of male diabetic patients over 50 years old suffer from erectile dysfunction, and erectile dysfunction caused by nerve and vascular damage caused by diabetes is particularly difficult to treat. Bayer's potent and selective phosphodiesterase 5 (PDE5) inhibitor, vardenafil, has the potential to be a boon for those with diabetes-induced erectile dysfunction. These drugs are used as disposable treatment drugs, and after oral administration about 1 hour before sexual intercourse, they increase the concentration of cGMP induced by selective inhibition of PDE5 action, nitric oxide (NO) released after blocking stimulation, relax arterial vascular smooth muscle, and enhance erectile function.
Three selective phosphodiesterase type 5 (PDE5) inhibitors: sildenafil (Cialis), vardenafil (Eride), and tadalafil are all first-line agents for ED; In terms of efficacy, safety and tolerability, PDE5 inhibitors were not significantly different from apomorphine; Intracavernous injection of prostaglandin E1 is a second-line treatment for ED; Intraurethral administration of prostaglandin E1 is less effective than intracavernous injection of prostaglandin E1. It is concluded that PDE5 inhibitors have the characteristics of effectiveness, good tolerability and safety in the treatment of ED. Apomorphine, intracavernous prostaglandin E1, and intraurethral administration of prostaglandin E1 are also effective and well tolerated.