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PT-141 and Sexual Dysfunction

PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile

dysfunction. Studies have shown that PT-141 does not act on the vascular system like former

compounds, but allegedly works by activating melanocortin receptors in the brain, therefore

helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has

shown effectiveness in clinical studies on both male and female rats. Male rats have shown

erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive

results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for

female rats, the observable results in female rats tend to be stronger.

Development

PT-141 was developed from the Melanotan 2 Peptide, which underwent testing as a sunless

tanning agent. In initial testing, Melanotan 2 did induce tanning, but additionally caused sexual

arousal and spontaneous erections as unexpected side effects in nine out of the ten original male

volunteer test subjects. Palatin completed patient treatment in its Phase 2B clinical trial in

premenopausal women with FSD Primary data analysis and announcement of top-line results

anticipated in first-half of fourth quarter of calendar year 2012. In studies, PT-141 was shown to

be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and

women (sexual arousal disorder). Unlike and other related medications, it does not act

upon the vascular system, but directly increases sexual desire via the nervous system.

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