|Solutions:||Dissolve 2.0g In Water And Dilute To 20ml With The Same Solvent.||1.Impurity A:||NMT 0.2%|
|Sulphated Ash:||Max.0.1%,determined On 1.0g||Assay:||98-101%(dried Substance)|
CAS 113-92-8 Chlorphenamine Maleate Powder,
Chlorphenamine Maleate Powder Relieve Allergy,
Relieve Allergy Antihistamine Powder
Chlorphenamine Maleate Pharmacy Sex Enhancement Powder Raw Materials 7054 11 7.
Appearance:white crystalline powder
Chlorphenamine maleate is a medicine known as an antihistamine. When the body comes into contact with something it is allergic to, such as pollen, animal hair or fur, house dust or insect bites, it produces a chemical called histamine. This causes itchy, watery eyes, running or blocked nose, sneezing and rashes, which may itch. Chlorphenamine maleate blocks the effects of histamine and so reduces these symptoms.
Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.
Chlorpheniramine inhibits the [3H]mepyramine binding to the histamine H1 receptor in guinea pig cortex with IC50 of 8.8 nM. Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM. Chlorpheniramine treatment in human salivary gland cells more significantly inhibits the histamine-induced [Ca2+]i increase in a concentration-dependent manner with IC50 of 128 nM than that of carbachol-induced [Ca2+]i increase with an IC50 of 43.9 μM.
The COA of Chlorpheniramine maleate:
|Product name||Chlorphenamine Maleate|
|CAS No.||113-92-8||Outer Packing||25kg/drum|
|Production date||Feb,2017||Shelf life||Jan,2022|
|Items of analysis||Specification||Results|
|Appearance||white or almost white,crystalline powder||complies|
|Solubility||Freely soluble in water,soluble in ethanol(96%)||complies|
|identification A.||melting point:130-135℃||131-132℃|
|B.||Infrared absorption spectrophotometry.||complies|
|C.||optical rotation:(see tests)||complies|
|solutions||dissolve 2.0g in water and dilute to 20ml with the same solvent||complies|
|appearance of solution||solution S is clear and not more intensely colored than reference solution BY6||complies|
|related substances||liquid chromatography||complies|
|1.Impurity A||NMT 0.2%||complies|
|2.Impurity B||NMT 0.1%||complies|
|3.Impurity C||NMT 0.1%||complies|
|4.Impurity D||NMT 0.1%||complies|
|5.Unspecified impurities||NMT 0.1%||complies|
|loss on drying||max.0.5%,determined on 1.000g by drying in an oven at 105℃ for 4h.||0.22%|
|sulphated ash||max.0.1%,determined on 1.0g||0.07%|
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