Weight Loss Pharmaceutical Grade East Butramine Hydrochloride Slimming Drug CAS125494-59-9

Weight Loss Drug Pharmaceutical Grade. Slimming Materials East Butramine Hydrochloride Slimming DrugCAS125494-59-9

Specification model: 98%

Properties: White or slightly white powder

This product is a central action obesity treatment. Its main mechanism is to inhibit the reuptake of norepinephrine, 5-hydroxytryptamine and dopamine and enhance satiety, but has no significant effect on the release of norepinephrine, 5-hydroxytryptamine and dopamine. < Pharmacokinetics > The average absorption rate of a single dose was 77%. The peak time of blood concentration was 1.2 hours. The oral clearance rate was 1750l/h, and the half-life was 11 hours. Through the hepatic first-pass effect, the cytochrome p450(3a4) isoenzymes of the liver are metabolized into pharmacologically active metabolites monodemethylated and dimethylated m1 and m2, and these activities are metabolized into pharmacologically active metabolites m5 and m6. The plasma concentrations of the drug form and its metabolites reached a peak within 3-4 hours after taking the drug, and the plasma concentrations of m1 and m2 reached a stable state within 4 days after taking the drug, and the concentration was twice as high as that of a single dose. Contraindications: ① patients with renal insufficiency ② hypertensive and diabetic patients usage and dosage: the recommended dose is 5-30mg once a day. If the weight loss is not significant for 2 weeks, the dosage can be increased to 40-500mg daily.